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KMID : 0854720120320040254
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Korean Journal of Asthma, Allergy and Clinical Immunology
2012 Volume.32 No. 4 p.254 ~ p.258
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Comparison of Laboratory Findings and Medication Levels according to Antologous Serum Skin Test Reactivity in Chronic Spontaneous Urticaria
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Lee Su-Kyoung
Cho Min-Ho
Kim Byoung-Yen
Kang Yun-Sung
Choi Seung-Heon
Sohn Seong-Wook
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Abstract
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Background: The autologous serum skin test is reported to be positive in up to 60% of patients with chronic spontaneous urticaria. However, the clinical role of autologous serum skin test is still poorly understood.
Methods: We reviewed the medical records of 166 chronic spontaneous urticaria patients whose symptoms lasted for more than 6 weeks and compared their laboratory findings and medication levels according to autologous serum skin test reactivity.
Results: Autologous serum skin test was positive in 69 (41.6%) chronic spontaneous urticaria patients. There were no significant differences between autologous serum skin test-positive and autologous serum skin test-negative groups in laboratory findings, such as anti-microsome antibody, anti-thyroglobulin antibody, anti-nuclear antibody, total immunoglobulin E, complement 4 level levels, rheumatoid factor, erythrocyte sedimentation rate and D-dimer. Autologous
serum skin test were not related to medication levels. Eight patients (11.6%) of autologous serum skin test-positive groups and 6 patients (6.2%) of autologous serum skin test-negative groups need level 4 medication (usage of cyclosporine, dapsone or anti-immunoglobulin E monoclonal antibody) to control urticaria without statistical significance.
Conclusion: Autologous serum skin test was positive in more than 40% of chronic spontaneous urticaria patients.
However, laboratory findings and medication levels were not affected by autologous serum skin test reactivity.
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KEYWORD
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Urticaria, Autologous serum skin test
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